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Abstract Introduction .  Paracetamol is the most commonly used drug across Western Europe and North America. There is no such trend of using Paracetamol in the Republic of Moldova, thus overdose cases are extremely rare. The mechanisms leading to overdose episodes might induce hepatotoxicity. Clinical case.  This present article reports a case of acute liver failure induced by Paracetamol overdose. A 46-year-old man presented to the Medpark International Hospital. He was administered...
Topics: Paracetamol, overdose, N-acetyl-cysteine, hepatotoxicity, acute liver failure
Abstract Introduction.  Whey is a by-product and an excellent source of proteins that is rather aggressive due to a large amount of organic substances it contains. The electro-activation of whey applied in the experiments is a wasteless method that allows the va-lorification of all whey components. β-lactoglobulin (β-Lg) makes up 50% of the whey proteins and 12% of the total protein content in milk. Material and methods.  The recovery of β-Lg in protein-mineral concentrates (PMC) by...
Topics: whey, protein-mineral concentrates, β-lactoglobulin, electroactivation
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Abstract Introduction .  The genus Lepraria includes diffuse or indefinitely delimited species, always sterile, Lendemer (1) naming it „the most unusual member of the sterile lichen crusts”. According to  Tonsberg (2) , the leprarioid state appeared as an adaptation to a substrate characterized by dry surfaces, in sites with high humidity and low illumination. The thallus is leprose with an entirely sorediate surface. The lack of fruiting bodies has made the lichens from this group among...
Topics: lichenized fungi, Lepraria, key, biodiversity
Abstract Introduction.  The present study assessed  Pseudomonas aeruginosa surface characteristics, motility and adhesion properties under the influence of 1-[4-(1,1,3,3-tetra methyl butyl) phenoxy]-3-(N-benzyl hexa methylene iminium)-2-propanol chloride (KVM-194). Material and methods.  The clinical strain P. aeruginosa 449 was used in the study. The cell surface hydrophobicity (CSH) was evaluated by adhesion to solvent (MATS test). Swimming, swarming and twitching motility of P....
Topics: Pseudomonas aeruginosa, hydrophobicity, motility, adhesion, biofilms
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Abstract Introduction.  Hip pain is common in childhood. The main dilemma is to differentiate between benign conditions and those causing significant morbidity and mortality. Material and methods.  A clinical case report of a toddler presenting with Musculoskeletal (MSK) mask due to a brain tumor. Results.  A 2-year-old boy presented to the ER complaining of hip pain, muscle weakness, and limping.  The neurologic exam showed no abnormalities. At the 3 rd  day of admission, patient...
Topics: astrocytoma, brain tumor, musculoskeletal mask, children
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Abstract Introduction.  Drinking water includes a multitude of natural elements, with a strong connection between them, which through the dynamics of their modification in many cases influence the health of the population. Material and methods.  The quality of drinking water from the Prut river ecosystem was studied (water from aqueducts fed from the river, water from artesian wells, water from adjacent wells), health status of the population from riparian localities (Lipcani, Ungheni and...
Topics: sanitary-chemical indicators of water, population morbidity, correlation, risk
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Abstract Introduction.  One of the major problems characterizing the nutritional status is the iron deficiency, which leads to decreased immunity, increased incidence of infectious diseases and anemia. Obviously, only well-thought-out corrections can solve these disorders.  Material and methods  In order to know the influence of the method of manufacture for iron-fortified products on the iron level, a series of in vivo research was carried out, on a batch of 21 white rats, Wistar line,...
Topics: iron anemia, rats, in vivo research, fortified bread, lactic acid fermentation peripheral blood...
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Abstract Introduction . Gram-negative bacilli belonging to the order Enterobacterales are normal inhabitants of the human gut, which also are the most common causative agents of both nosocomial and community acquired infections in patients of all ages.  Although not even a century has passed since Fleming's discovery of penicillin, the scientists have been alarmed by the fact that the "last resort antibiotics" viz. carbapenems have been compromised. Material and methods.  The...
Topics: carbapenem-resistant Klebsiella, pneumoniae, carbapenem resistant, Enterobaacterales, carbapenems,...
Abstract Introduction . Autoinflammatory diseases are a group of genetically inherited disorders and familial Mediterranean fever is the most common of this group. It is rare in other than Middle East populations. Clinical manifestations of FMF are attacks of fever usually shorter than 24 hours, associated with arthritis, pleuritic chest pain, and abdominal pain. Case presentation .  A 15-year-old female patient was included in the study. She complained of recurrent episodes of fever...
Topics: autoinflammatory diseases, familial Mediterranean fever, children
Abstract Introduction . The rapid development of information technologies has provided challenges and opportunities for effective documentation of plant genetic resources (PGR). Access to information on PGR is essential for their conservation and sustainable utilization. Material and methods.  Information System on PGR in Republic of Moldova – ReGen was created to manage the data on PGR conservation at the national level and represents unified system that includes three basic functional...
Topics: conservation, gene bank, plant genetic resources, information system, documentation
Abstract Introduction.  The major and most common mechanisms for almost all antimicrobial substances is the induction of oxidative stress responses within the pathogen cells by accumulation of free radicals, which mediate a whole range of classical antimicrobial mechanisms of action observed by researchers. Thus, this present study was conducted to reveal some biochemical changes regarding the antioxidant status of pathogenic microorganisms under the influence of novel chemical compounds...
Topics: antimicrobial activity, antioxidant activity, chemical compounds, copper, reference strains
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Abstract Introduction.  Pathological left ventricular (LV) remodeling in children with metabolic syndrome (MS) is associated with a significant increase in cardiometabolic risk. However, data regarding the prevalence of LV remodeling patterns in children with MS are limited. Material and methods.  An observational analytical cohort study was conducted on 145 children. The diagnosis of MS was established according to the International Diabetes Federation (IDF) criteria. We analyzed the...
Topics: metabolic syndrome, children, left ventricular remodeling, patterns
Abstract Introduction .  Some causative agents of sapro-zoonotic infections can multiply in the external environment (water reservoirs, soils, plants), as well as in animals, including microorganisms of the genus Yersinia. Material and methods.   Isolation and identification of Y. pseudotuberculosis was carried out in accordance with the instructions on “Epidemiology, laboratory diagnosis of yersiniosis, organization and conduct of preventive and anti-epidemiological measures”. Antibiotic...
Topics: Yersinia pseudotuberculosis, cultivation, temperature, phenotypic, traits, antibiotics, resistance,...
Abstract Introduction.  Leptospirosis is a zoonosis caused by microorganisms of the genus Leptospira with a global spread. The  main  reservoir of leptospires are the small mammals, which survive after infection, spreading the causative agent in the environment with urine. Material and methods.   The studied were conducted in 2017-2019 in different  ecosystems , where 1617 small mammals were collected, investigated for the presence of specific antibodies to Leptospira  spp . Ecological...
Topics: small mammals, Leptospira spp., leptospirosis, ecosystem, biotope
Abstract Introduction . Meningococcal infection (MI) and N. meningitidis carriage are widespread. The global incidence represents a total of 500,000-1,200,000 cases per year, of which 50,000-135,000 are fatal. In European countries the incidence is 0.6-2.0 per 100,000. Infants and young people are more likely to get affected due to different genotypes of meningococci. Thus, MI surveillance is required. Material and methods.  The research purpose was to perform an epidemiological analysis of MI...
Topics: meningococcal infection, epidemiology, morbidity
Abstract Introduction.  In the Republic of Moldova, the first case of COVID-19 was confirmed on March 7, followed by a significantly increasing incidence across the country. It is important to describe the clinical and epidemiological aspects that were adjusted to the national context in order to develop and implement optimal public health care measures. Material and methods . A cross-sectional descriptive study was conducted from March 7 to April 6, 2020, using the surveillance system data of...
Topics: COVID-19, infection, Republic of Moldova, prevention, epidemiological study
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Abstract Introduction.  Currently, there is a steadily increasing trend in losses due to flooding. Nevertheless, global warming, followed by an inevitable overuse of river valleys might further contribute to an increase in the frequency and destructive power of floods. It is quite important to trace the cause and effect chain of the economic, social and ecological impacts during the flood hazard. Material and methods.  A bibliographic research was carried out by using historical and...
Topics: flood, calamities, victims, medical management
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Abstract Introduction.  As a result of increased production and spread in the environment, nanoparticles can pose a significant risk to public health. To date, the toxicity data of nanoparticles collected, using traditional models and methods, are contradictory and inconsistent. Highlighting the significant methods and markers of nanoparticle toxicity is a current research direction. Material and methods.  The strain of red microalgae Porphyridium cruentum CNM-AR-01, known as a lipid...
Topics: nanoparticles, toxicity tests, malondialdehyde, Porphyridium cruentum
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Abstract Introduction.  Representatives of the genus Staphylococcus spp. cause a significant proportion of diseases in animals and humans. Nowadays the problem of their acquired antibiotic resistance is an urgent concern. Material and methods.  Isolation and identification of Staphylococcus spp. carried out in accordance with DSTU EN 6888:2003 standard. The  susceptibility  of the strains to antibiotics was determined by the disk diffusion method. Interpretation of the results was carried...
Topics: Staphylococcus spp., plasma coagulation, biological properties, antibiotics, susceptibility,...
Abstract Introduction.  Many rodent species are important pests for agriculture and for urban areas. The long-eared owl is a predator that exerts constant pressure on rodent density. Material and methods . The studies were performed in winters of 2011-2013 in the cities of Chisinau and Bacau, where 599 and 82 pellets of Asio otus were collected, respectively. The prey items were identified from cranial bones extracted from pellets. Results.  Long-eared owl’s diet in both sites consists of...
Topics: Asio otus, urban environment, trophic spectrum, rodents, Microtus voles
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Abstract   Introduction.  A safe way to reduce the onset of oncological diseases is to protect the population from exposure to radon. In order to know the risk of radon influence on the health of the population, it is necessary to quantify the radon concentrations in the homes air and environment components. Material and methods.  The aim of the study was to monitor radon concentrations in the air from different types of housing (n=2500), in rural and urban areas, on the territory of the...
Topics: radon, public health, risk
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Abstract Introduction.  It is estimated that over 15% of couples of reproductive age face infertility worldwide. In about half of these cases the male factor is involved. To assess the potential of male fertility the spermiogram analysis may not always be an optimal diagnostic tool, but it remains the basic clinical tool. Material and methods.  The purpose of the study is to analyze the regional tendencies of the semen quality in male partners of couples facing infertility. A retrospective...
Topics: human semen, male infertility diagnosis, reference values
Abstract Introduction.  Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease among children of the first year of life, especially children born prematurely with extremely low and very low body weight. Material and methods.  To estimate the number of children born alive in Perm Territory between 2015 and 2017, official statistics data were used. Experimental epidemiological studies were used to assess safety, reactogenicity, immunogenic activity and preventive efficacy of...
Topics: PCV13 vaccine, pneumococcal infection, bronchopulmonary dysplasia
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Abstract Introduction.  Antimicrobial resistance is a global public health problem that the world is facing today. Material and methods.  Isolation and identification of Salmonella spp. were performed according to DSTU EN 12824: 2004; DSTU ISO 18593: 2006 standards; Nutrient media were manufactured in accordance with DSTU EN ISO 11133: 2014 standard. The antibiotic susceptibility of cultures was determined by the disk diffusion method. The research findings were both studied and interpreted...
Topics: Salmonella spp., biological properties, antibiotics, resistance, susceptibility
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Abstract Introduction . Viral hepatitis C (HCV) is a significant global health problem. The risk of developing chronic HCV is up to 80% of patients, of whom 10-20% can develop liver cirrhosis or hepatocellular carcinoma which can lead to death. Treatment with direct-acting antiviral agents (DAAs) contributes to a sustained virological response (SVR) in 97-99% of cases. Material and methods.  The study was conducted on 206 patients with chronic HCV who underwent two generic antiviral agent...
Topics: chronic HCV, treatment, sofosbuvir, ledipasvir, daclatasvir, treatment, sofosbuvir, ledipasvir,...